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Human immunodeficiency virus (HIV) is a virus that causes acquired immunodeficiency syndrome (AIDS). Infection primarily happens through unprotected sex when infected semen, vaginal fluid or blood comes into contact with the mucous membranes of the partner. In practise, this means the vagina or anus. It is also possible to become infected through ejaculation into the mouth, but less likely, because the natural enzymes in spit attack the virus.