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As a psychiatric diagnosis, the word 'depression' only hails back to around 1850. Before that, the word 'melancholia' was used to describe the condition. Depression is a mental disorder, first and foremost characterised by an all-encompassing low mood accompanied by low self-esteem and loss of interest. Other symptoms are insomnia, a reduced sex drive and a lack of concentration. It is believed that a depressed person's brain is lacking serotonin, which is therefore often given as a treatment.